In another embodiment, the antiviral compound is a protease inhibitor. In addition, ORF3, the longest among the SARS specific gene, is the only one that encodes for a peptide containing a high number of predicted O-glycosylation sites (Table 11). lung, liver, kidney) and also samples of in vitro cell culture constituents including but not limited to conditioned media resulting from the growth of cells and tissues in culture medium e.g. The invention further comprising a polynucleotide sequence encoding the polypeptides of (a) or (b). The animals are primed at day 0 and boosted at 3 and 6 weeks. No. The hydrophobic domains may also be used to generate antibodies specific to those regions to treat or prevent SARS virus infection. An immunoassay for detecting a SARS virus antigen in a sample, comprising the step of contacting the sample with the antibody of any one of claims 13 to 17.19. However, as used herein, these terms all refer to a virion-like unit containing an alphavirus-derived RNA vector replicon. The method for propagating the SARS virus in cultured cells (e.g., mammalian cells) includes the steps of inoculating the cultured cells with SARS virus, cultivating the infected cells for a desired time period for virus propagation, such as for example as determined by SARS virus titer or SARS virus antigen expression (e.g., between 24 and 168 hours after inoculation) and collecting the propagated virus. A variant of SEQ ID NO: 6052 that is included within the invention is SEQ ID NO: 9964. Such vaccines follow the model of current influenza vaccines. Saponin formulations, may also be used as adjuvants in the invention. The polynucleotide regions of probes may be composed of DNA, and/or RNA, and/or synthetic nucleotide analogs. Amino acids suitable for use in the invention include, for example, L-glutamine, arginine, cysteine, and lysine. Typical diluents include, for example, various types of starch, lactose, mannitol, kaolin, calcium phosphate or sulfate, inorganic salts such as sodium chloride and powdered sugar. If it is not secreted, it can be isolated from cell lysates. Such compositions may also comprise adjuvants, such as wetting agents, emulsifying and suspending agents, cyclodextrins, and sweetening, flavoring, and perfuming agents. As used herein the phrase “targeted DNA segment” is used to mean a DNA sequence encoding, in whole or in part, an mRNA for a targeted protein, including introns or exons, where suppression is desired. Virus-Like Particles Comprising SARS Antigens The SARS viral antigens of the invention may be formulated into Virus Like Particles (“VLPs”). The vaccine of claim 29, wherein said virus is inactivated by chemical or physical means.31. One example of a resin for use in this purification method is Matrex™ Cellufine™ Sulfate (MCS). The invention further provides for the administration of a steroidal anti-inflammatory drug in combination with at least one antiviral compound, for example, from the antiviral compounds described in the documents listed in Table 1 and Table 2 by inhalation. Membrane was blocked in blocking buffer (5% skim milk and 0.1% Tween 20 in PBS) and incubated with indicated antibody at room temperature for 1 hr, washed and probed with horseradish peroxidase (HRP)-conjugated secondary antibody (Biosource) followed by chemiluminescence (ECL system, Amersham) and exposed by X-ray films.
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